Quote:
Originally posted by Ozzy
I have tried to find some info on this product but i come up with nothing. Do you have some info? links? or anything i can read on it please?
Cheers
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Go to
www.synthetek.com to find a distributor in your area.
This is info on Syntheburn that I just pulled off another site.
INGREDIENTS:
Each serving (2 capsules) contains Ephedrine 20mg (MaHuang Extract 250mg),
Caffeine 200mg (Guarana Extract 910mg), Synephrine 12mg (Citurs Aurantium
200mg), L-Tyrosine 100mg, Ginger 100mg
120 capsule bottle
SyntheBURN™ is a powerful thermogenic agent formulated by combining the
best fat burners on the market today.
You tried other ECA based stacks in the past? Try this one! NOTHING compares to it! Use it before a workout and be amazed by the energy levels you will experience and the amount of extra weights you will lift!
SyntheBURN™ is an extremely efficient fat burner, as evidenced by the fact
that it is the primary choice of professional athletes when they require to burn
bodyfat.
As well as being an excellent fat burner, SyntheBURN™ is a very efficient energy booster, succesfully replacing the traditional morning or pre-workout cup of coffee.
SyntheBurn™ was designed with competitive athletes in mind. The watered
down versions of ECA stacks on the market just would not work for a
competitive bodybuilder so
Synthetek Industries took the EC stack to the next
level. The ingredients synergistically combine to make one of the most potent
thermogenic agents on the market. SyntheBurn™ focuses on the production
and efficiency of the neurotransmitters that control and produce thermogenic
activity. Every ingredient plays an essential role in the overall effectiveness of
SyntheBurn™ and it's thermogenic activity.
MA HUANG (STANDARDISED FOR 20mg OF EPHEDRINE ALKALOIDS)
Ephedrine works by stimulating nerve terminals of the sympathetic nervous
system to release noradrenaline. Noradrenaline (NA) is the neurotransmitter
responsible for thermogenesis, appetite, and sex drive among other things. NA
in turn stimulates all adrenergic receptors (AR), Beta-1, Beta-2 and Beta-3AR.
After prolonged use of Ephedrine the Beta-1 and Beta-2AR's downregulate.
Now comes the interesting part unlike a certain popular bodybuilding diet drug
that is a selective AR mediator, Ephedrine is non-selective which allows it to
continually work even after the Beta-1 and Beta-2AR's have down regulated.
The role of the Beta-3 adrenergic receptor: The Beta-3AR is resistant to
downregulation and has increases thermogenesis in prolonged use of
Ephedrine. Forty percent of ephedrine's thermogenic effect is mediated from
Beta-3 receptor activation. Beta-3AR are abundant in brown fat and non-
selective adrenergic receptor agents such as ephedrine activate brown fat
thermogenesis. Ephedrine also stimulates brown fat growth. An increase in
brown fat leads to increased thermogenesis. So this means there is no reason to
cycle the use of ephedrine based products. Prolonged use of Ephedrine has
continued thermogenesis by activating the beta-3AR. Prolonged use also
alleviates the most notable side effects, raised heart rate and blood pressure.
So in conclusion Ephedrine alkaloids work synergistically to stimulate beta
adrenoceptors, suppress appetite, elevate mood and continue to work with
prolonged use safe and effectively. (1-4)
GUARANA EXTRACT (STANDARDISED FOR 200mg CAFFEINE)
Caffeine is a central nervous system (CNS) stimulant that enhances and
prolongs thermogenesis by working synergistically with ephedrine.
The mechanism in which caffeine enhances the thermogenic process is by
inhibiting the release of phosphodiesterase. Why is this important? Well let's
look.
The ephedrine increases noradrenaline (NA) which in turn increases
thermogenesis through Beta-1,2 and 3 adrenergic receptors. Caffeine synergistically enhances the effect of ephedrine by blocking Phosphodiesterase.
Phosphodiesterase (PDE) inhibits the release of noradrenaline-induced cAMP.
NA-induced cAMP cAMP acts as a messenger in the cascade of thermogenic
activity induced by ephedrine. If NA is not produced or is inhibited then the
message never gets sent, thus ceasing thermogenesis.
In studies a specific ratio of ephedrine and caffeine exerted a supra-additive
synergism, whereas the thermogenic effects of lower doses of caffeine only had
an additive effect. This ratio is 20/200mg ephedrine /caffeine. SyntheBurn™ has
maintained this ratio. (2-4)
CITRUS AURANTIUM (STANDARDISED FOR 12mg OF SYNEPHRINE)
Synephrine is very similar in structure to ephedrine. But has a much milder
stimulant effect. Synephrine's thermogenic activity is mediated by activating the
Beta-3AR located in brown fat. The selective release of noradrenaline and
adrenaline in the beta-3 receptor site does not cross the blood-brain barrier,
which allows an increase in metabolic rate without affecting heart rate or blood
pressure.
Lets not forget the role both Ephedrine and Synephrine play in bronchial
dilation. Increasing oxygen uptake only further increases the efficiency of
thermogenesis. (5-7)
L-TYROSINE 100mg
L-Tyrosine has many synergistic functions in this
fat loss arsenal. It is a
precursor to the thyroid hormone T3, neurotransmitters adrenaline,
noradrenaline (NA), and dopamine. Not only does tyrosine aid thyroid function
but most importantly it maximizes the efficiency of NA. Tyrosine adds to the
arsenal of ingredients in SyntheBURN™ that optimize NA production and
thermogenesis.
Conclusion:
SyntheBURN™ has been designed to be one of the most potent and effective fat
loss aids on the market by combining ingredients that are proven to not only
work effectively by themselves but to synergistically enhance the traditional
Ephedrine Caffeine stack.
Ephedrine is the catalyst of the formula by stimulating noradrenaline production
and targeting beta-1,2 and 3 adrenergic receptors. Caffeine and Ginger inhibit
enzymes that block noradrenaline while enhancing the effects of Ephedrine.
Synephrine directly targets beta-3 adrenergic receptors to stimulate brown fat
thermogenesis. L-tyrosine not only regulates thyroid but also provides the
precursor to noradrenaline that is ultimately stimulated by Ephedrine. As you
can see, syntheBURN™ was designed to comprehensively target the entire
thermogenic process.
1.) Liu YL, Toubro S, Astrup A, Stock MJ <STRONG>"Contribution of
beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in
humans" Int J Obes Relat Metab Disord 1995 Sep, Vol 19 (9), Pg
678-85, PMID: 0008574280.
2.) Toubro S, Astrup A, Breum L, Quaade F <STRONG>"The acute and
chronic effects of ephedrine/caffeine mixtures on energy expenditure and
glucose metabolism in humans." Int J Obes Relat Metab Disord
1993 Dec, Vol 17 (Suppl 3), Pg S73-7; discussion S82, PMID: 0008124407.
Dulloo AG and Stock MJ "Ephedrine in the treatment
3.) Astrup A and Toubro S "Thermogenic, metabolic, and cardiovascular
responses to ephedrine and caffeine in man"Int J Obes Relat Metab Disord
1993, Vol 17 Suppl 1 Pg S41-3, PMID: 0008384179.
4.) Astrup A, Toubro S, Cannon S, Hein P, Madsen J "Thermogenic
synergism between ephedrine and caffeine in healthy volunteers: a double-blind,
placebo-controlled study" Metabolism 1991, Vol 40 (3), Pg 323-9, PMID:
0002000046.
5) PMID: 0001109569.
American Journal of Clinical Nutrition. 70(6):1040-5, 1999
6) Carpene C, et al. "Selective activation of beta 3-adrenoreceptors by
octopamine: comparative studies in mammalian fat cells." Naunyn
Schmiedebergs Arch Pharmacol 1999 Apr;359(4):310-21
7) Lorenz MW. Synthesis of lipids in the fat body of Gryllus bimaculatus: age-dependency and regulation by adipokinetic hormone.
Arch Insect Biochem Physiol. 2001 Aug;47(4):198-214.
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