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post cycle
Originally posted by twistedneck
Kronah, do you agree with the studies that show clomid mimics LH like hcg (in addition to stimulating Petuitary to release LH). No studes exist for nolvadex on this but they are quite similar..
I think a lot of people think of Clomid and nolva as two entirely different drugs when in fact they are quite similar in how they function in the body. Clomid simply works by decreasing the number of cytoplasmic estrogenic receptors by acting as an estrogen block. Basically Clomid (clomiphene) simply binds to the receptor and keeps it inactive. As a result, the body stimulates the secretion of luteinizing hormone (LH) and follicular stimulating hormone (FSH) and gonadotropins, which in turn stimulate the leydig cells to secrete higher amounts of testosterone. So to answer your question, yes I believe that Clomid does in fact indirectly stimulates the anterior pituitary gland to secrete LH and FSH.
Now lets talk a little about Nolvadex. Nolvadex is used in medicine as an anti-estrogen for females with breast cancer and in women who have estrogen secreting tumors. It is also used in the treatment of gynecomastia as well as mastalgia. It has never been marketed for anything else so much of the medical studies are geared to the topics above. Studies conducted in the late 1970’s at the University of Ghent in Belgium make clear the advantages of using Nolvadex instead of Clomid for increasing testosterone levels. To sum up the article, the results showed that Nolvadex used for 10 days at 20mg a day increased testosterone levels by 142% which almost the same as using Clomid for 10 days at 150mg a day. I think people forget that these drugs are cousins in their molecular structure. They both belong to the same group of triphenylethylenes compounds. I think either one of the two can be used effectively for post recovery therapy.
As far as running Arimidex post cycle, this question is somewhat controversial. I personally do when I run Clomid because I find that my acne does not break out as bad if if I run Arimidex at .25mg a day. If I am running Nolvadex on the other hand I do not use Arimidex. Remember Arimidex negatively effects your lipid profiles so I would advocate using it the least amount of time as possible. Hope this answers your questions.
Also, what about finishing off with arimidex (concurrent with clom and nolva) to bump back up the FHS levels?
Thansk, TW [/B][/QUOTE]
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