Quote:
Originally posted by KAOTIKCHEM
Gram per gram Letrozole is cheaper than Anastrozole.
However an effective dose of Letrozole is around 2.5 times as much as an effective dose of Anastrozole depending on the goals that the drug is trying to achieve.
(i.e. Average dose of Anastrozole is 1mg and average dose of letrozole is 2.5mg)
So once you take this into consideration you will find that the price per dose Letrozole is slightly more expensive.
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Recommended doses are designed to attain the maximum efficacy with the minimum dose. That does not mean that letrozole is less effective than anastrazole gm/gm. It means that the maximum reduction in estrogen for anastrazole was seen at 1 mg/day. Anything higher did not reduce the estrogen to lower levels (on average). Letrozole, on the other hand, shows greater reduction of estrogen at 2.5 mg/day than at 1 mg/day. Note that the max reduction of estrogen for letro is better than the max reduction for arimidex.
Letrozole, even at 0.5 mg/day, showed estrogen reductions in some subjects of almost 100%. This was not evident in the arimidex studies.
I agree with Ry's comments: letrozole is better for more experienced clients. Arimidex is great for less experienced people. I also believe that long term users should maintain at least some level of estrogen for its beneficial effects (BMD, etc).
Finally, I question the use of Exemestane, since one of its metabolites has a significant affinity for the AR. The affinity of the metabolite is about 25% the affinity of DHT. The bad news is: it is an AR blocker, not agonist.
SJ