BROMOCRIPTINE

[BUFFDADDY]

How is bromocriptine used in body-building?

[Statix]

i haven't used it, but it supposedly helps prevent progestrogen related gyno...

[rj420]

it suppresses prolactin levels (often the cause of puffy nips), increases dopamine levels (used for alzheimer's and parkinson's). Suppresses appetite by mimicking the hormone leptin. This is the hormone that lowers when you have been on a diet for a lengthy time, and you body tells you to eat (the binge). Many bros have been using it for fina gyno, dieting, hormonal regulation. Side effects are nausea and fatigue about 1-2 hours after consumption, but these usually fade within a week once the body becomes accustomed to it. Looks like a damn good bodybuilding drug to me.

[pharmD]

I think that I should let you know one other SERIOUS side effect, Fatal Liver toxicity. I think they take enough liver toxic drugs as it is. bromocriptine (parlodel is the brand name) is not used much anymore in practice b/c of this reason, they now use the non-ergot alkaloids like ropinirole, and pramipexole. I think when we start using anti-parkinson drugs, we probably weren't mean to bodybuild in the first place.

[Ivan]

Good post pharmD

You a pharmacist?

[rj420]

not trying to doubt you pharmD, but can you explain this for us? I had researched bromo before and never found liver toxicity to be an issue... here is a study from pubmed....

Bromocriptine treatment of systemic lupus erythematosus.

Walker SE.

Department of Internal Medicine, The University of Missouri-Columbia, 65212, USA. sewk@tranquility.net

Prolactin, a peptide hormone, acts as a cytokine. It has been hypothesized that bromocriptine, a dopamine analog that suppresses pituitary secretion of prolactin, suppresses circulating prolactin and, through this mechanism, has the potential to suppress autoimmune disease. This rationale has been applied to the treatment of systemic lupus erythematosus (SLE), a prototype autoimmune illness that occurs spontaneously in animal models such as the F1 hybrid NZBxNZW mouse, and in humans. Treatment with bromocriptine was effective in treating some induced and spontaneous autoimmune disease in experimental models. Bromocriptine did slow the course of SLE in NZBxNZW mice when treatment was started before the appearance of clinical disease. In addition, bromocriptine was effective in treating established disease in this model. In three separate clinical trials, bromocriptine showed evidence that it had a therapeutic effect in treating human lupus. Bromocriptine is currently considered an unproven therapy for SLE. Its use is entirely experimental.

*****The fact that bromocriptine was effective in treating NZBxNZW mice, the beneficial therapeutic effects in human trials, and the LOW TOXICITY of the drug form a solid rationale for undertaking further therapeutic trials.******

PMID: 11721704 [PubMed - indexed for MEDLINE]


Just curious here. Would it be toxic to the liver with short-termed usage? Or is it clinically shown to be toxic over extended time frames, such as used for alzheimer's and parkinson's?